| http://purl.uniprot.org/citations/9079630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9079630 | http://www.w3.org/2000/01/rdf-schema#comment | "The glucocorticoid receptor (GR) is a ligand-activated transcription factor. In this study, we used the yeast two-hybrid system to isolate cDNAs encoding proteins that interact with the human GR ligand-binding domain (LBD) in a ligand-dependent manner. One isolated cDNA from a HeLa cell library encoded the COOH-terminal portion of the eta-isoform of the 14-3-3 protein (residues 187-246). Glucocorticoid agonists, triamcinolone acetonide and dexamethasone, induced the GR LBD/14-3-3eta protein fragment interaction, but an antagonist, RU486, did not. Glutathione S-transferase pull-down experiments in vitro showed that full-length 14-3-3eta protein also interacted with the activated GR. Transient transfection studies using COS-7 cells revealed a stimulatory effect of 14-3-3eta protein on transcriptional activation by the GR. The 14-3-3 family members have recently been found to associate with a number of important signaling proteins, such as protein kinase C and Raf-1, as functional modulators. Our findings suggest a novel regulatory role of 14-3-3eta protein in GR-mediated signaling pathways and also point to a mechanism whereby GR may cross-talk with other signal transduction systems."xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.13.8153"xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/author | "Wakui H."xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/author | "Zilliacus J."xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/author | "Wright A.P."xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/author | "Gustafsson J."xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/pages | "8153-8156"xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/title | "Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein."xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9079630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9079630 |
| http://purl.uniprot.org/citations/9079630 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9079630 |
| http://purl.uniprot.org/uniprot/Q04917#attribution-26EB3E45299BC17E0FD344BE59F2C7E0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9079630 |