| http://purl.uniprot.org/citations/9079637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9079637 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies showed that the Hox homeodomain proteins from paralog groups 1-8 display cooperative DNA binding with the non-Hox homeodomain protein Pbx, mediated by a canonical YPWM. Although the Abd-B-like Hox proteins in paralogs 9-13 lack this sequence, Hoxb-9 and Hoxa-10 were reported to bind with Pbx1a to DNA. We show that these interactions require a tryptophan 6 amino acids N-terminal to the homeodomain. Binding site selection for Hoxb-9 with Pbx1a yielded ATGATTTACGAC, containing a novel TTAC Hox-binding site adjacent to a Pbx site. In the presence of Pbx1a, Hoxb-9 and Hoxa-10 bound to targets containing either TTAC or TTAT. These data extend previous findings that interactions with Pbx define a Hox protein binding code for different DNA sequences across paralog groups 1 through 10. Members of the 11, 12, and 13 paralogs do not cooperatively bind DNA with Pbx1a, despite the presence of tryptophan residues N-terminal to the homeodomain in Hoxd-12 and Hoxd-13. Hoxa-11, Hoxd-12, or Hoxd-13, in the presence of Pbx1a, selected a TTAC Hox site but lacking a Pbx1a site. These data suggest that Abd-B-like Hox proteins bind to a novel TTAC site and can be divided by their cooperative binding to DNA with Pbx1a."xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.13.8198"xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/author | "Shen W.F."xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/author | "Largman C."xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/author | "Rozenfeld S."xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/author | "Lawrence H.J."xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/pages | "8198-8206"xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/title | "The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target."xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9079637 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9079637 |
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