| http://purl.uniprot.org/citations/9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9084409 | http://www.w3.org/2000/01/rdf-schema#comment | "The VGF gene encodes a secretory protein that is expressed in a cell type-restricted pattern in neuroendocrine cells and is up-regulated by nerve growth factor (NGF) in the rat pheochromocytoma PC12 cell line. Here we report the isolation and characterization of the 5'-terminal region of the human VGF gene. In addition to a TATA box and a CCAAT box located at canonical distances from the transcription start site, the human VGF promoter contains several consensus sequences for different transcription factors, including a cyclic AMP response element and an AP-1 element, several GC boxes, and sequences homologous to other neuronal promoters. Transient transfection analysis demonstrates that 2.3 kb of the 5'-flanking sequence acts as a tissue-specific promoter, efficiently used only by neuronal cells that express endogenous VGF. Deletion analysis reveals that a positive regulatory region is located between nucleotides -458 to -204. Negative cis-acting elements that repress promoter activity in cell lines that do not normally express VGF are located between nucleotides -2,305 and -573 and between -458 and -204. The 5'-flanking region of the human VGF gene confers responsiveness to NGF, cyclic AMP, and phorbol ester treatment."xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.1997.68041390.x"xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/author | "Canu N."xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/author | "Possenti R."xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/author | "Levi A."xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/author | "Rinaldi A.M."xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/author | "Trani E."xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/pages | "1390-1399"xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/title | "Molecular cloning and characterization of the human VGF promoter region."xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/9084409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9084409 |
| http://purl.uniprot.org/citations/9084409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9084409 |
| http://purl.uniprot.org/uniprot/#_P15336-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
| http://purl.uniprot.org/uniprot/#_O15240-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
| http://purl.uniprot.org/uniprot/#_Q13127-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
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| http://purl.uniprot.org/uniprot/#_P18846-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
| http://purl.uniprot.org/uniprot/#_P50553-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
| http://purl.uniprot.org/uniprot/#_Q09472-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
| http://purl.uniprot.org/uniprot/#_P18146-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
| http://purl.uniprot.org/uniprot/#_Q99081-mappedCitation-9084409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9084409 |
| http://purl.uniprot.org/uniprot/Q13127 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9084409 |