RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/9096311http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9096311http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9096311http://www.w3.org/2000/01/rdf-schema#comment"This paper describes the identification of a new family of mammalian genes that encode secreted proteins containing homology to the cysteine-rich ligand-binding domain found in the frizzled family of transmembrane receptors. The secreted frizzled-related proteins (sFRPs) are approximately 30 kDa in size, and each contains a putative signal sequence, a frizzled-like cysteine-rich domain, and a conserved hydrophilic carboxy-terminal domain. The sFRPs are not the products of differential splicing of the known frizzled genes. Glycosylphosphatidylinositol-anchored derivatives of sFRP-2 and sFRP-3 produced in transfected human embryonic kidney cells confer cell-surface binding by the Drosophila Wingless protein. These observations suggest that sFRPs may function in vivo to modulate Wnt signaling, or, alternatively, as novel ligands for as yet unidentified receptors."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.org/dc/terms/identifier"doi:10.1073/pnas.94.7.2859"xsd:string
http://purl.uniprot.org/citations/9096311http://purl.org/dc/terms/identifier"doi:10.1073/pnas.94.7.2859"xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Copeland N.G."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Copeland N.G."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Gilbert D.J."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Gilbert D.J."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Jenkins N.A."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Jenkins N.A."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Hsieh J.-C."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Hsieh J.-C."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Nathans J."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Nathans J."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Rattner A."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Rattner A."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Smallwood P.M."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/author"Smallwood P.M."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/pages"2859-2863"xsd:string
http://purl.uniprot.org/citations/9096311http://purl.uniprot.org/core/pages"2859-2863"xsd:string