| http://purl.uniprot.org/citations/9097953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9097953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9097953 | http://www.w3.org/2000/01/rdf-schema#comment | "Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine tract within the SCA1 gene product, ataxin-1. Expansion of this tract is believed to result in a gain of function by the mutant protein, perhaps through altered self-associations or interactions with other cellular proteins. We have used the yeast two hybrid system to determine if ataxin-1 is capable of multimerization. This analysis revealed that ataxin-1 does have the ability to self-associate, however, this association does not appear to be influenced by expansion of the polyglutamine tract. Consistent with this finding, deletion analysis excluded the involvement of the polyglutamine tract in ataxin-1 self-association, and instead localized the multimerization region to amino acids 495-605 of the wild type protein. These results, while identifying an ataxin-1 self-interaction region, fail to support a proposed model of polar-zipper mediated multimerization involving the ataxin-1 polyglutamine tract."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/6.4.513"xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/6.4.513"xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Zoghbi H.Y."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Zoghbi H.Y."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Burright E.N."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Burright E.N."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Davidson J.D."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Davidson J.D."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Duvick L.A."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Duvick L.A."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Koshy B."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/author | "Koshy B."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/pages | "513-518"xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/pages | "513-518"xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/title | "Identification of a self-association region within the SCA1 gene product, ataxin-1."xsd:string |
| http://purl.uniprot.org/citations/9097953 | http://purl.uniprot.org/core/title | "Identification of a self-association region within the SCA1 gene product, ataxin-1."xsd:string |