| http://purl.uniprot.org/citations/9098075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9098075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9098075 | http://www.w3.org/2000/01/rdf-schema#comment | "A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) and its specific receptor protein (ArpA) are required for streptomycin production and aerial mycelium formation in Streptomyces griseus. A mutant strain HO1 that produced streptomycin and formed aerial mycelium and spores was derived from an A-factor-deficient mutant, S. griseus HH1. The phenotypes of mutant HO1 were found to result from a single amino acid replacement of ArpA; the proline residue at position 115 in the wild-type ArpA was replaced by serine, yielding mutant ArpA (P115S). The mutant ArpA (P115S) was still able to form a homodimer and possessed A-factor-binding ability but lost the ability to bind DNA. The properties of P115S suggest that ArpA consists of two independently functional domains, one for A-factor binding and one for DNA binding, and that proline-115 plays an important role in DNA binding. This is in agreement with the idea that A-factor binding to the COOH-terminal domain of ArpA causes a subtle conformational change of the distal NH2-terminal DNA-binding domain, resulting in dissociation of ArpA from DNA."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.179.8.2748-2752.1997"xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.179.8.2748-2752.1997"xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/author | "Horinouchi S."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/author | "Horinouchi S."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/author | "Onaka H."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/author | "Onaka H."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/author | "Sugiyama M."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/author | "Sugiyama M."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/pages | "2748-2752"xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/pages | "2748-2752"xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/title | "A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/title | "A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability."xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/9098075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9098075 |
| http://purl.uniprot.org/citations/9098075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9098075 |
| http://purl.uniprot.org/citations/9098075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9098075 |
| http://purl.uniprot.org/citations/9098075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9098075 |