| http://purl.uniprot.org/citations/9110258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9110258 | http://www.w3.org/2000/01/rdf-schema#comment | "Alternative splicing of precursor RNA enables a single gene to encode multiple protein isoforms with different functional characteristics and tissue distributions. Differential splicing of Drosophila Shaker (Sh) gene transcripts regulates the tissue-specific expression of kinetically distinct potassium ion channels throughout development. Regulation of Sh alternative splicing is being examined in germline transformants using lacZ as a reporter gene. P-element constructs were generated in which one or both of the two mutually exclusive Sh 3' acceptor sites were positioned in the same translational reading frame as the lacZ coding sequences. The constructs were introduced into the germline and the transgenic animals examined for tissue-specific beta-galactosidase expression patterns. Some tissues exhibit "promiscuous" splicing; these tissues are competent to splice to either 3' acceptor even when both are present on the same pre-mRNA. In other tissues splice choice results from competition between the two 3' sites; these tissues can splice to either site when it is the only available 3' acceptor, but when given a choice will splice to only one of the two 3' acceptors. In some tissues, splicing occurs exclusively at only one of the 3' acceptor sites; these tissues are not competent to splice to one of the sites even if it is the only 3' acceptor present on the pre-mRNA. These results suggests that multiple, distinct regulatory modes are operating to control tissue-specific alternative splicing of Sh 3' domains and are discussed in terms of potential underlying mechanisms for regulating the tissue-specific expression of alternatively spliced genes."xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.org/dc/terms/identifier | "doi:10.1002/(sici)1097-4695(199705)32:5<457::aid-neu2>3.3.co;2-f"xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/author | "Iverson L.E."xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/author | "Germeraad S.E."xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/author | "Mottes J.R."xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/author | "Yeager S.A."xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/name | "J Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/pages | "457-468"xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/title | "Tissue-specific alternative splicing of Shaker potassium channel transcripts results from distinct modes of regulating 3' splice choice."xsd:string |
| http://purl.uniprot.org/citations/9110258 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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