| http://purl.uniprot.org/citations/9111214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9111214 | http://www.w3.org/2000/01/rdf-schema#comment | "Transgenic Apc1638N mice, heterozygous for a targeted frameshift mutation at codon 1638 of the endogenous adenomatous polyposis coli (APC) gene, are predisposed to develop multiple adenomas and adenocarcinomas along the intestinal tract and to a number of extra-intestinal lesions including, among others, mammary tumors. We have studied these mice in a short-term carcinogenicity test with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a potent murine small intestinal mutagen and lymphomagen. Upon dietary administration of 0.03% PhIP in a short-term (6 months) study, a significantly increased number of small intestinal tumors as well as an increased number of aberrant crypt foci (ACF) were observed in male Apc+/Apc1638N mice compared with untreated transgenic mice. No differences in intestinal and mammary tumor multiplicity were observed between treated and control Apc+/Apc1638N females."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/18.4.777"xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/author | "Fodde R."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/author | "Thorgeirsson S.S."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/author | "Kristiansen E."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/author | "Mortensen A."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/author | "van Kranen H."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/author | "Sorensen I.K."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/author | "van Kreijl C."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/pages | "777-781"xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/title | "Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/9111214 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9111214 |
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| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-9111214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9111214 |
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| http://purl.uniprot.org/uniprot/#_Q8BRD8-mappedCitation-9111214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9111214 |
| http://purl.uniprot.org/uniprot/#_Q3UQT2-mappedCitation-9111214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9111214 |