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| http://purl.uniprot.org/citations/9114032 | http://www.w3.org/2000/01/rdf-schema#comment | "Deletions and other genome rearrangements are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (pun) mutation in the mouse is caused by duplication of a 70-kb internal fragment of the p gene. Spontaneous reversion events in homozygous pun/pun mice occur through deletion of a duplicated sequence. Reversion events in premelanocytes in the mouse embryo detected as black spots on the gray fur of the offspring were inducible by the carcinogen x-rays, ethyl methanesulfonate, methyl methanesulfonate, ethyl nitrosourea, benzo[a]pyrene, trichloroethylene, benzene, and sodium arsenate. The latter three carcinogens are not detectable with several in vitro or in vivo mutagenesis assays. We studied the molecular mechanism of the carcinogen-induced reversion events by cDNA analysis using reverse transcriptase-PCR method and identified the induced reversion events as deletions. DNA deletion assays may be sensitive indicators for carcinogen exposure."xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.9.4576"xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/author | "Aubrecht J."xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/author | "Schiestl R.H."xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/author | "Carls N."xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/author | "Khogali F."xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/pages | "4576-4581"xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/title | "Carcinogens induce reversion of the mouse pink-eyed unstable mutation."xsd:string |
| http://purl.uniprot.org/citations/9114032 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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