| http://purl.uniprot.org/citations/9115204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9115204 | http://www.w3.org/2000/01/rdf-schema#comment | "The human neurofibromatosis type 1 (NF1) tumor suppressor protein functions as a Ras-specific guanosine triphosphatase-activating protein, but the identity of Ras-mediated pathways modulated by NF1 remains unknown. A study of Drosophila NF1 mutants revealed that NF1 is essential for the cellular response to the neuropeptide PACAP38 (pituitary adenylyl cyclase-activating polypeptide) at the neuromuscular junction. The peptide induced a 100-fold enhancement of potassium currents by activating the Ras-Raf and adenylyl cyclase-adenosine 3',5'-monophosphate (cAMP) pathways. This response was eliminated in NF1 mutants. NF1 appears to regulate the rutabaga-encoded adenylyl cyclase rather than the Ras-Raf pathway. Moreover, the NF1 defect was rescued by the exposure of cells to pharmacological treatment that increased concentrations of cAMP."xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.276.5313.795"xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/author | "Zhong Y."xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/author | "Bernards A."xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/author | "Hannan F."xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/author | "Guo H.F."xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/author | "The I."xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/pages | "795-798"xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/title | "Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides."xsd:string |
| http://purl.uniprot.org/citations/9115204 | http://purl.uniprot.org/core/volume | "276"xsd:string |
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