| http://purl.uniprot.org/citations/9121437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9121437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9121437 | http://www.w3.org/2000/01/rdf-schema#comment | "A 50-kDa cellular factor, E4F, has been implicated in mediating trans activation of the adenovirus E4 gene by the 289R E1A(13S) protein. Previous experiments demonstrated an E1A-dependent increase in E4F DNA binding activity, dependent on phosphorylation, that correlated with the activation of E4 transcription. Using expression screening, we isolated a cDNA clone encoding the E4F protein, as judged by DNA binding characteristics, transcriptional activation, and immunological criteria. The E4F-1 cDNA encodes a 783-amino-acid polypeptide that has 86% sequence identity with the murine nuclear factor phiAP3, a GLI-krüppel-related protein. E4F DNA binding activity is encoded within an amino-terminal region of E4F-1 that contains a zinc finger domain and, as with endogenous E4F, is phosphatase sensitive. We found that E4F was generated from the full-length E4F-1-encoded protein as a 50-kDa amino-terminal fragment. Moreover, E1A(13S) expression induced the phosphorylation of both forms of E4F-1 but differentially regulated their DNA binding activities, stimulating the 50-kDa fragment while reducing the activity of the full-length protein. In transient-transfection assays, the E4F-1 amino-terminal fragment stimulated the adenovirus E4 promoter in the presence of E1A(13S), whereas the full-length protein repressed the promoter in the absence, but not the presence, of E1A. The results indicate that the 50-kDa polypeptide responsible for E4F DNA binding activity is a fragment generated from the human homolog of phiAP3 and that the two forms of the E4F-1 protein are differentially regulated by E1A through phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.4.1890"xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.4.1890"xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/author | "Rooney R.J."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/author | "Rooney R.J."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/author | "Fernandes E.R."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/author | "Fernandes E.R."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/pages | "1890-1903"xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/pages | "1890-1903"xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/title | "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/title | "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3."xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9121437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9121437 |
| http://purl.uniprot.org/citations/9121437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9121437 |
| http://purl.uniprot.org/citations/9121437 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9121437 |
| http://purl.uniprot.org/citations/9121437 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9121437 |
| http://purl.uniprot.org/uniprot/Q66K89 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9121437 |
| http://purl.uniprot.org/embl-cds/AAD09139.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9121437 |