| http://purl.uniprot.org/citations/9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9130661 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor necrosis factors (TNF-alpha and lymphotoxin, or LT-alpha) are important mediators of the immune and inflammatory responses, and it has been proposed that a positive feedback loop could boost the expression of the TNF to sufficiently high levels to fend off infections. To investigate this phenomenon and its biological consequences, we have generated LT-alpha/TNF-alpha knockout mice and compared mice having one or two functional LT-alpha/TNF-alpha alleles. In response to lipopolysaccharide (LPS) stimulation, TNF-alpha levels in the circulation or in the supernatant of macrophage cultures were 20-to 100-fold lower in heterozygous samples than in their wild-type counterparts. This differential increased with the intensity of stimulation and throughout the response, supporting the involvement of a positive feedback loop. Moreover, the heterozygous mice had an increased bacterial load following Listeria monocytogenes infection and exhibited a bimodal response to the association of D-galactosamine and LPS which was similar to that of wild-type mice at low doses of LPS and more like that of homozygous mutants at high doses. These results therefore establish the biological importance of the nonlinear response of TNF-alpha levels to gene dosage, and these mice provide a unique tool to study how the propensity to produce TNF can determine the immunological fitness of individuals."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.1830270434"xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Milon G."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Dautry F."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Boussadia O."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Cases S."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Cavaillon J.M."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Fitting C."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Lebastard M."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/author | "Amiot F."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/pages | "1035-1042"xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/title | "Mice heterozygous for a deletion of the tumor necrosis factor-alpha and lymphotoxin-alpha genes: biological importance of a nonlinear response of tumor necrosis factor-alpha to gene dosage."xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/9130661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9130661 |
| http://purl.uniprot.org/citations/9130661 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9130661 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9130661 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9130661 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA2-mappedCitation-9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9130661 |
| http://purl.uniprot.org/uniprot/#_A4FUI4-mappedCitation-9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9130661 |
| http://purl.uniprot.org/uniprot/#_G3V002-mappedCitation-9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9130661 |
| http://purl.uniprot.org/uniprot/#_Q3U0Q5-mappedCitation-9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9130661 |
| http://purl.uniprot.org/uniprot/#_Q3U593-mappedCitation-9130661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9130661 |