| http://purl.uniprot.org/citations/9136770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9136770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9136770 | http://www.w3.org/2000/01/rdf-schema#comment | "C. elegans aex-3 mutations cause pleiotropic behavioral defects that are suggestive of reduced synaptic transmission. aex-3 mutations also show strong genetic interactions with mutations in unc-31 and unc-64, two other genes implicated in synaptic transmission. Physiological and pharmacological studies indicate that aex-3 defects are presynaptic. In aex-3 mutants, the synaptic vesicle-associated RAB-3 protein aberrantly accumulates in neuronal cell bodies and is reduced in synapse-rich axons. This localization defect is specific to RAB-3, since other synaptic proteins are localized normally in aex-3 mutants. aex-3 encodes a 1409 amino acid protein with strong homology to DENN, a human protein of unknown function. In C. elegans, aex-3 is expressed in all or nearly all neurons. These results suggest that AEX-3 is a novel regulator of presynaptic activity that interacts with RAB-3 to regulate synaptic vesicle release."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)80302-5"xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)80302-5"xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Iwasaki K."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Iwasaki K."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Thomas J.H."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Thomas J.H."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Staunton J."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Staunton J."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Nonet M."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Nonet M."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Saifee O."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/author | "Saifee O."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/pages | "613-622"xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/pages | "613-622"xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/title | "aex-3 encodes a novel regulator of presynaptic activity in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/title | "aex-3 encodes a novel regulator of presynaptic activity in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/9136770 | http://purl.uniprot.org/core/volume | "18"xsd:string |