DESCRIBE <http://purl.uniprot.org/citations/9136836>

Subject	Predicate	Object
http://purl.uniprot.org/citations/9136836	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9136836	http://www.w3.org/2000/01/rdf-schema#comment	" Background & aims The pathogenesis of Hirschsprung's disease is not well understood. The suitability of the animal model for the unknown pathogenesis of inhibitory neurotransmission in Hirschsprung's disease was investigated. Methods Circular smooth muscle strips from the internal anal sphincter (IAS) and distal colon (2, 6, 8, 16, and 24 mm from the anal verge) from normal and Ls/Ls mice (mice homozygous for the lethal spotting mutation that develop fetal megacolon after aganglionosis of the terminal colon) were prepared to record changes in isometric tensions in response to different agents and nonadrenergic, noncholinergic nerve stimulation by electrical field stimulation. Results Bethanechol was used to produce contraction of the smooth muscle strips of distal colon to record a decrease in the tension. Conversely, the IAS smooth muscle strips developed spontaneous tone. In the normal homozygous mice, electrical field stimulation caused a biphasic response, an initial decrease followed by an after-contraction, whereas in Ls/Ls mice, the predominant response was contraction. All smooth muscle strips from normal and Ls/Ls mice produced relaxation in response to sodium nitroprusside and vasoactive intestinal polypeptide. Conclusions Ls/Ls mice may serve as an appropriate animal model to investigate the pathogenesis of the inhibitory neurotransmission in Hirschsprung's disease in the distal colon and IAS."xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.org/dc/terms/identifier	"doi:10.1016/s0016-5085(97)70039-8"xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/author	"McHugh K.M."xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/author	"Rattan S."xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/author	"Chakder S."xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/date	"1997"xsd:gYear
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/name	"Gastroenterology"xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/pages	"1575-1585"xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/title	"Inhibitory neurotransmission in lethal spotted mutant mice: a model for Hirschsprung's disease."xsd:string
http://purl.uniprot.org/citations/9136836	http://purl.uniprot.org/core/volume	"112"xsd:string
http://purl.uniprot.org/citations/9136836	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/9136836
http://purl.uniprot.org/citations/9136836	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/9136836
http://purl.uniprot.org/uniprot/#_E0CZ86-mappedCitation-9136836	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/#_A2APU5-mappedCitation-9136836	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/#_P48299-mappedCitation-9136836	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/#_P48302-mappedCitation-9136836	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/#_Q8BJE1-mappedCitation-9136836	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/A2APU5	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/P48299	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/P48302	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/E0CZ86	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/9136836
http://purl.uniprot.org/uniprot/Q8BJE1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/9136836