| http://purl.uniprot.org/citations/9139683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9139683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9139683 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/9139683 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently described the isolation and sequence analysis of a DNA region containing the genes of Bacillus stearothermophilus heptaprenyl diphosphate synthase, which catalyzes the synthesis of the prenyl side chain of menaquinone-7 of this bacterium. Sequence analyses revealed the presence of three open reading frames (ORFs), designated as ORF-1, ORF-2, and ORF-3, and the structural genes of the heptaprenyl diphosphate synthase were proved to consist of ORF-1 (heps-1) and ORF-3 (heps-2) (Koike-Takeshita, A., Koyama, T., Obata, S., and Ogura, K. (1995) J. Biol. Chem. 270, 18396-18400). The predicted amino acid sequence of ORF-2 (234 amino acids) contains a methyltransferase consensus sequence and shows a 22% identity with UbiG of Escherichia coli, which catalyzes S-adenosyl-L-methionine-dependent methylation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone. These pieces of information led us to identify the ORF-2 gene product. The cell-free homogenate of the transformant of E. coli with an expression vector of ORF-2 catalyzed the incorporation of S-adenosyl-L-methionine into menaquinone-8, indicating that ORF-2 encodes 2-heptaprenyl-1,4-naphthoquinone methyltransferase, which participates in the terminal step of the menaquinone biosynthesis. Thus it is concluded that the ORF-1, ORF-2, and ORF-3 genes, designated heps-1, menG, and heps-2, respectively, form another cluster involved in menaquinone biosynthesis in addition to the cluster of menB, menC, menD, and menE already identified in the Bacillus subtilis and E. coli chromosomes."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.19.12380"xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.19.12380"xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/author | "Ogura K."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/author | "Ogura K."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/author | "Koyama T."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/author | "Koyama T."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/author | "Koike-Takeshita A."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/author | "Koike-Takeshita A."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/pages | "12380-12383"xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/pages | "12380-12383"xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/title | "Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/title | "Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus."xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9139683 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9139683 |
| http://purl.uniprot.org/citations/9139683 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9139683 |
| http://purl.uniprot.org/citations/9139683 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9139683 |