| http://purl.uniprot.org/citations/9139699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9139699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9139699 | http://www.w3.org/2000/01/rdf-schema#comment | "The beta-chemokine macrophage inflammatory protein-1alpha (MIP-1alpha) is chemotactic for many hemopoietic cell types and can inhibit hemopoietic stem cell (HSC) proliferation, effects mediated through G-protein coupled heptahelical receptors. We have isolated cDNAs for seven chemokine receptors, CCR-1 to -5, MIP-1alphaRL1, and a novel cDNA, D6. Chinese hamster ovary cells expressing CCR-1, -3, -5, and D6 bound 125I-murine MIP-1alpha: the order of affinity was D6 > CCR-5 > CCR-1 > CCR-3. Each bound a distinct subset of other beta-chemokines: the order of competition for 125I-murine MIP-1alpha on D6 was murine MIP-1alpha > human and murine MIP-1beta > human RANTES approximately JE > human MCP-3 > human MCP-1. Human MIP-1alpha and the alpha-chemokines did not compete. Like other chemokine receptors, D6 induced transient increases in [Ca2+] in HEK 293 cells upon ligand binding. D6 mRNA was abundant in lung and detectable in many other tissues. Bone marrow cell fractionation demonstrated T-cell and macrophage/monocyte expression of D6, and CCR-1, -3, and -5. Moreover, we could detect expression of CCR-3, CCR-5, and to a greater extent D6 in a cell population enriched for HSCs. Thus, we have characterized four murine beta chemokine receptors that are likely involved in mediating the pro-inflammatory functions of MIP-1alpha and other chemokines, and we present D6, CCR-3, and CCR-5 as candidate receptors in MIP-1alpha-induced HSC inhibition."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.19.12495"xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.19.12495"xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Graham G.J."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Graham G.J."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Nibbs R.J."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Nibbs R.J."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Pragnell I.B."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Pragnell I.B."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Wylie S.M."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/author | "Wylie S.M."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/pages | "12495-12504"xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/pages | "12495-12504"xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/title | "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/title | "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5."xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9139699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9139699 |
| http://purl.uniprot.org/citations/9139699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9139699 |