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http://purl.uniprot.org/citations/9144225http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9144225http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9144225http://www.w3.org/2000/01/rdf-schema#comment"An Fcalpha receptor probe of human origin was used to identify novel members of the Ig gene superfamily in mice. Paired Ig-like receptors, named PIR-A and PIR-B, are predicted from sequence analysis of the cDNAs isolated from a mouse splenic library. Both type I transmembrane proteins possess similar ectodomains with six Ig-like loops, but have different transmembrane and cytoplasmic regions. The predicted PIR-A protein has a short cytoplasmic tail and a charged Arg residue in the transmembrane region that, by analogy with the FcalphaR relative, suggests the potential for association with an additional transmembrane protein to form a signal transducing unit. In contrast, the PIR-B protein has an uncharged transmembrane region and a long cytoplasmic tail containing four potential immunoreceptor tyrosine-based inhibitory motifs. These features are shared by the related killer inhibitory receptors. PIR-A proteins appear to be highly variable, in that predicted peptide sequences differ for seven randomly selected PIR-A clones, whereas PIR-B cDNA clones are invariant. Southern blot analysis with PIR-B and PIR-A-specific probes suggests only one PIR-B gene and multiple PIR-A genes. The PIR-A and PIR-B genes are expressed in B lymphocytes and myeloid lineage cells, wherein both are expressed simultaneously. The characteristics of the highly-conserved PIR-A and PIR-B genes and their coordinate cellular expression suggest a potential regulatory role in humoral, inflammatory, and allergic responses."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.org/dc/terms/identifier"doi:10.1073/pnas.94.10.5261"xsd:string
http://purl.uniprot.org/citations/9144225http://purl.org/dc/terms/identifier"doi:10.1073/pnas.94.10.5261"xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/author"Burrows P.D."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/author"Burrows P.D."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/author"Cooper M.D."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/author"Cooper M.D."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/author"Kubagawa H."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/author"Kubagawa H."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/name"Proc. Natl. Acad. Sci. U.S.A."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/pages"5261-5266"xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/pages"5261-5266"xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/title"A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/title"A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells."xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/volume"94"xsd:string
http://purl.uniprot.org/citations/9144225http://purl.uniprot.org/core/volume"94"xsd:string
http://purl.uniprot.org/citations/9144225http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9144225
http://purl.uniprot.org/citations/9144225http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9144225
http://purl.uniprot.org/citations/9144225http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9144225
http://purl.uniprot.org/citations/9144225http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9144225