| http://purl.uniprot.org/citations/9144489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9144489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9144489 | http://www.w3.org/2000/01/rdf-schema#comment | "The bcl-x gene, a bcl-2 family member, is highly regulated during lymphoid development, and its expression modulates apoptosis in lymphoid and other cell populations. Several forms of bcl-x mRNAs with different biologic functions have been described in rodents and humans. In this study, we have determined the organization and promoter region of the mouse bcl-x gene in an effort to understand the molecular basis for the different bcl-x mRNA species identified in tissues. We show that mouse bcl-x maps to the distal mouse chromosome 2 at approximately 89 cM, and exhibits a three-exon structure with an untranslated first exon and a facultative first intron. The coding region of bcl-xL is generated by the juncture of exons II and III through a splicing reaction, whereas bcl-xS is generated by an alternatively utilized donor splice site located within exon II. Analysis of multiple cDNAs and primer extension experiments revealed major transcription initiation sites in brain and thymus within a GC-rich region, with multiple Sp1-binding motifs located upstream of exon I. Another promoter was mapped to a 57-bp region localized upstream of the translation initiation codon by transfection of reporter constructs into FL5.12 and K562 cell lines. The remarkable similarity between the genomic regions of bcl-2 and bcl-x suggests that these genes have evolved from a common ancestral gene or through gene duplication."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Duan L."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Duan L."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Inohara N."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Inohara N."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Gonzalez-Garcia M."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Gonzalez-Garcia M."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Ohta S."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Ohta S."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Seldin M.F."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Seldin M.F."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Ekhterae D."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Ekhterae D."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Grillot D.A."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/author | "Grillot D.A."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/pages | "4750-4757"xsd:string |
| http://purl.uniprot.org/citations/9144489 | http://purl.uniprot.org/core/pages | "4750-4757"xsd:string |