| http://purl.uniprot.org/citations/9150947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9150947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9150947 | http://www.w3.org/2000/01/rdf-schema#comment | "Renal cell carcinoma (RCC), a human kidney cancer from the proximal tubular epithelium, accounts for about 3% of adult malignancies. Molecular and cytogenetic analysis have highlighted deletions, translocations, or loss of heterozygosity in the 3p21-p26, a putative RCC locus, as well as in 6q, 8p, 9pq, and 14pq. Studies on phenotypic expression of human kidney tissue and on post-translational modifications in RCC have not yet provided a marker for early renal cell carcinoma diagnosis. Current diagnostic methods do not help to detect the tumor before advanced stages. We therefore used two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) to study normal and tumor kidney tissues in ten patients suffering from RCC. A human kidney protein map in the SWISS-2DPAGE database accessible through the ExPASy WWW Molecular Biology Server was established. Of 2789 separated polypeptides, 43 were identified by gel comparison, amino acid analysis, N-terminal sequencing, and/or immunodetection. The comparison between normal and tumor kidney tissues showed four polypeptides to be absent in RCC. One of them was identified as ubiquinol cytochrome c reductase (UQCR), whose locus has elsewhere been tentatively assigned to chromosome 19p12 or chromosome 22. A second polypeptide was identified as mitochondrial NADH-ubiquinone oxido-reductase complex I whose locus is located on chromosome 18p11.2 and chromosome 19q13.3. These result suggest that the lack of UQCR and of mitochondrial NADH-ubiquinone oxidoreductase complex I expression in RCC may be caused by unknown deletions, or by changes in gene transcription or translation. It might indicate that mitochondrial disfunction plays a major role in RCC genesis or evolution."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.org/dc/terms/identifier | "doi:10.1002/elps.1150180343"xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.org/dc/terms/identifier | "doi:10.1002/elps.1150180343"xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Frutiger S."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Frutiger S."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Hochstrasser D.F."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Hochstrasser D.F."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Hughes G.J."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Hughes G.J."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Sanchez J.-C."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Sanchez J.-C."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Golaz O."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Golaz O."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Wilkins M.R."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Wilkins M.R."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Marocchi A."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Marocchi A."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Cappellano F."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Cappellano F."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Doro G."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Doro G."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Giannone B."xsd:string |
| http://purl.uniprot.org/citations/9150947 | http://purl.uniprot.org/core/author | "Giannone B."xsd:string |