| http://purl.uniprot.org/citations/9154809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9154809 | http://www.w3.org/2000/01/rdf-schema#comment | "A semipermissive growth condition was defined for a Schizosaccharomyces pombe strain carrying a thermosensitive allele of DNA polymerase delta (pol delta ts03). Under this condition, DNA polymerase delta is semidisabled and causes a delay in S-phase progression. Using a genetic strategy, we have isolated a panel of mutants that enter premature mitosis when DNA replication is incomplete but which are not defective for arrest in G2/M following DNA damage. We characterized the aya14 mutant, which enters premature mitosis when S phase is arrested by genetic or chemical means. However, this mutant is sensitive to neither UV nor gamma irradiation. Two genomic clones, rad26+ and cds1+, were found to suppress the hydroxyurea sensitivity of the aya14 mutant. Genetic analysis indicates that aya14 is a novel allele of the cell cycle checkpoint gene rad26+, which we have named rad26.a14. cds1+ is a suppressor which suppresses the S-phase feedback control defect of rad26.a14 when S phase is inhibited by either hydroxyurea or cdc22, but it does not suppress the defect when S phase is arrested by a mutant DNA polymerase. Analyses of rad26.a14 in a variety of cdc mutant backgrounds indicate that strains containing rad26.a14 bypass S-phase arrest but not G1 or late S/G2 arrest. A model of how Rad26 monitors S-phase progression to maintain the dependency of cell cycle events and coordinates with other rad/hus checkpoint gene products in responding to radiation damage is proposed."xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.6.3103"xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/author | "Uchiyama M."xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/author | "Griffiths D.J."xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/author | "Wang T.S."xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/author | "Galli I."xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/pages | "3103-3115"xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/title | "A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis."xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9154809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9154809 |
| http://purl.uniprot.org/citations/9154809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9154809 |
| http://purl.uniprot.org/uniprot/#_P30316-mappedCitation-9154809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9154809 |
| http://purl.uniprot.org/uniprot/#_P36632-mappedCitation-9154809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9154809 |
| http://purl.uniprot.org/uniprot/P30316 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9154809 |
| http://purl.uniprot.org/uniprot/P36632 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9154809 |