| http://purl.uniprot.org/citations/9154835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9154835 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokine receptors activate multiple signal transduction pathways, resulting in the induction of specific target genes. We have recently identified a hematopoietic cell-specific immediate-early gene, DUB-1, that encodes a growth-regulatory deubiquitinating enzyme. The DUB-1 gene contains a 112-bp enhancer element that is specifically induced by the beta c subunit of the interleukin-3 (IL-3) receptor. To investigate the mechanism of DUB-1 induction, we examined the effects of dominant-negative forms of JAK kinases, STAT transcription factors, and Raf-1 in transient transfection assays. In Ba/F3 cells, IL-3 induced a dose-dependent activation of DUB-1-luciferase (luc) and GAS-luc reporter constructs. A dominant-negative form of JAK2 (truncated at amino acid 829) inhibited the induction of DUB-1-luc and GAS-luc by IL-3. A dominant-negative form of STAT5 (truncated at amino acid 650) inhibited the induction of GAS-luc but not DUB-1-luc. A dominant-negative form of Raf-1 inhibited the induction of DUB-1-luc but had no effect on the induction of GAS-luc by IL-3. The requirement for JAK2 in the stimulation of the DUB-1 enhancer was further supported by the suppression of DUB-1 induction in Ba/F3 cells stably expressing the dominant-negative JAK2 polypeptide. We hypothesize that IL-3 activates a JAK2/Raf-1 signaling pathway that is required for DUB-1 induction and is independent of STAT5."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.6.3364"xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/author | "D'Andrea A.D."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/author | "Mathey-Prevot B."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/author | "Jaster R."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/author | "Pless M."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/pages | "3364-3372"xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/title | "JAK2 is required for induction of the murine DUB-1 gene."xsd:string |
| http://purl.uniprot.org/citations/9154835 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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