| http://purl.uniprot.org/citations/9155013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9155013 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor Nur77 (NGFI-B), a member of the steroid nuclear receptor superfamily, is induced to a high level during T-cell receptor (TCR)-mediated apoptosis. A transgenic dominant-negative Nur77 protein can inhibit the apoptotic process accompanying negative selection in thymocytes, while constitutive expression of Nur77 leads to massive cell death. Nur77-deficient mice, however, have no phenotype, suggesting the possible existence of a protein with redundant function to Nur77. To explore this possibility, we have characterized the role of two Nur77 family members, Nurr1 and Nor-1, in TCR-induced apoptosis. We found that Nor-1 and Nurr1 can transactivate through the same DNA element as Nur77, and that their transactivation activities can be blocked by a Nur77 dominant-negative protein. In thymocytes, Nor-1 protein is induced to a very high level upon TCR stimulation and has similar kinetics to Nur77. In contrast, Nurr1 is undetectable in stimulated thymocytes. Furthermore, constitutive expression of Nor-1 in thymocytes leads to massive apoptosis and up-regulation of CD25, suggesting a functional redundancy between Nur77 and Nor-1 gene products. As in the case of our Nur77-FL mice, FasL is not detectable in the thymocytes of Nor-1 transgenic mice. Constitutive expression of Nur77 in gld/gld mice rescues the lymphoproliferative phenotype of the FasL mutant mice. Thus, Nor-1 and Nur77 demonstrate functional redundancy in an apparently Fas-independent apoptosis."xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.8.1865"xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/author | "Chan F.K."xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/author | "Winoto A."xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/author | "Cado D."xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/author | "Cheng L.E."xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/pages | "1865-1875"xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/title | "Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/9155013 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9155013 |
| http://purl.uniprot.org/citations/9155013 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9155013 |
| http://purl.uniprot.org/uniprot/P12813#attribution-2EE75545EE61EA34C090110DAA532431 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9155013 |
| http://purl.uniprot.org/uniprot/Q9QZB6#attribution-2EE75545EE61EA34C090110DAA532431 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9155013 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VJZ1-mappedCitation-9155013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9155013 |
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| http://purl.uniprot.org/uniprot/#_A2VCP6-mappedCitation-9155013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9155013 |
| http://purl.uniprot.org/uniprot/#_F6R7A2-mappedCitation-9155013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9155013 |
| http://purl.uniprot.org/uniprot/#_Q7TMV9-mappedCitation-9155013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9155013 |
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| http://purl.uniprot.org/uniprot/#_Q9QZB6-mappedCitation-9155013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9155013 |