| http://purl.uniprot.org/citations/9157947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9157947 | http://www.w3.org/2000/01/rdf-schema#comment | "The main function of plasminogen activator inhibitor type 1 (PAI-1) is to decrease fibrinolysis, which leads to fibrin accumulation. An elevated plasma PAI-1 concentration has been identified as a risk factor for the development of myocardial infarction, and an association between 1 polymorphism of the PAI-1 promoter and plasma PAI-1 levels has been described. Our aim was to identify new polymorphisms in the PAI-1 gene and to further examine the relationship between PAI-1 genotypes and circulating PAI-1 levels. We report the presence of 4 new polymorphisms that were identified by non-isotopic single-strand conformational polymorphism analysis followed by sequencing. These polymorphisms were investigated in relation to PAI-1 levels in a sample of 256 healthy men, aged 50-59 years, from France and Northern Ireland. Two G/A substitutions were detected at positions -844 and +9785. The former is in strong positive linkage disequilibrium with the previously described 4G/5G polymorphism at position -675. Two polymorphisms in the 3' untranslated region were identified. One corresponds to a T/G substitution at position +11,053 and is in negative linkage disequilibrium with the G/A substitution (+9785). The other is a 9-nucleotide insertion/deletion located between nucleotides +11,320 and +11,345 in a threefold-repeated sequence. This polymorphism is in strong positive linkage disequilibrium with the G/A substitution (+9785). The overall heterozygosity provided by the 5 PAI-1 polymorphisms (including the 4 new variants and the 4G/5G polymorphism) was .77. No significant association was found between PAI activity and genotypes; furthermore, the well known associations between PAI activity and body mass index, serum triglycerides, or insulin were homogeneous according to PAI-1 genotypes."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.atv.17.5.851"xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Henry M."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Peiretti F."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Cambien F."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Amouyel P."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Arveiler D."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Poirier O."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Evans A."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Juhan-Vague I."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Alessi M.C."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Ferrieres J."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Chomiki N."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/author | "Scarabin P.Y."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/pages | "851-858"xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/title | "Five frequent polymorphisms of the PAI-1 gene: lack of association between genotypes, PAI activity, and triglyceride levels in a healthy population."xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9157947 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9157947 |
| http://purl.uniprot.org/citations/9157947 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9157947 |
| http://purl.uniprot.org/uniprot/#_A0A5B9RUH0-mappedCitation-9157947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9157947 |
| http://purl.uniprot.org/uniprot/#_B7Z1D9-mappedCitation-9157947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9157947 |
| http://purl.uniprot.org/uniprot/#_B7Z4X6-mappedCitation-9157947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9157947 |