| http://purl.uniprot.org/citations/9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9160753 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factor Sp1 has been implicated in the expression of many genes. Moreover, it has been suggested that Sp1 is linked to the maintenance of methylation-free CpG islands, the cell cycle, and the formation of active chromatin structures. We have inactivated the mouse Sp1 gene. Sp1-/-embryos are retarded in development, show a broad range of abnormalities, and die around day 11 of gestation. In Sp1-/-embryos, the expression of many putative target genes, including cell cycle-regulated genes, is not affected, CpG islands remain methylation free, and active chromatin is formed at the globin loci. However, the expression of the methyl-CpG-binding protein MeCP2 is greatly reduced in Sp1-/-embryos. MeCP2 is thought to be required for the maintenance of differentiated cells. We suggest that Sp1 is an important regulator of this process."xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80243-3"xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/author | "Marin M."xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/author | "Grosveld F."xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/author | "Philipsen S."xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/author | "Visser P."xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/author | "Karis A."xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/pages | "619-628"xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/title | "Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation."xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://purl.uniprot.org/core/volume | "89"xsd:string |
| http://purl.uniprot.org/citations/9160753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9160753 |
| http://purl.uniprot.org/citations/9160753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9160753 |
| http://purl.uniprot.org/uniprot/#_D3Z7U4-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STX7-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_D3YY81-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_E9Q0S7-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_E9Q113-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_P13864-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_Q0VDW2-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_A0A140LHU8-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRC0-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT69-mappedCitation-9160753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9160753 |