| http://purl.uniprot.org/citations/9164947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9164947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9164947 | http://www.w3.org/2000/01/rdf-schema#comment | "In chronic hepatitis C, Fas expression is up-regulated in the hepatocytes, especially near liver-infiltrating lymphocytes, and Fas ligand is expressed on the lymphocytes. The presence of hepatitis C virus (HCV)-specific CTLs has been demonstrated both in peripheral blood and among liver-infiltrating lymphocytes of patients with chronic hepatitis C. We studied the killing mechanisms of HCV-specific human CTLs using target cells that were sensitive or resistant to agonistic anti-Fas Abs and TNF-alpha. We show that HCV-specific CTL clones kill non-Ag-bearing bystander cells as well as Ag-bearing cells, although the bystander killing is less efficient than the specific target cell killing, and the efficacy of the bystander killing of anti-Fas- and soluble TNF-alpha-sensitive cells is greater than that of resistant cells. We also show that the killing of Ag-presenting, sensitive cells is mediated by Fas ligand and TNF-alpha as well as perforin, although the latter plays a major role in the killing at a low E:T ratio, and that the killing of sensitive bystander cells is primarily mediated by Fas ligand and TNF-alpha on CTLs expressed upon specific Ag stimulation, which may be relevant to the bystander lysis by HCV-specific CTLs of uninfected hepatocytes, in which Fas expression is up-regulated. Activated CTLs also kill bystander cells by the perforin-based mechanism, although it requires a high E:T ratio. The effective bystander killing requires a close intercellular contact between CTLs and target cells, although TNF-alpha released from the CTLs mediates lysis of the bystander cells without a close cell-cell contact."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Kaneko T."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Kaneko T."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Okumura K."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Ando K."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Ando K."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Moriyama T."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Moriyama T."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Muto Y."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Muto Y."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Kayagaki N."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Kayagaki N."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Hiroishi K."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Hiroishi K."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Imawari M."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/author | "Imawari M."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/9164947 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |