| http://purl.uniprot.org/citations/9164977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9164977 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice homozygous for a disrupted TGF-beta1 allele develop multiple lymphoproliferative disorders similar to those seen in the pseudolymphoma of Sjögren's syndrome. At 2 wk of age, these TGF-beta1 mutant mice begin to develop wasting syndrome and die at around 4 to 5 wk of age. We studied salivary glands from symptomatic mutant mice >14 days of age. Reverse transcriptase-PCR analysis showed up-regulation of proinflammatory cytokine genes such as IL-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-10, and IFN-gamma in these mutant mice. Enhanced expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule (VCAM-1), and MHC class II as well as CD4-positive T lymphocyte infiltration was detected by immunostaining. To elucidate the role of MHC class II, salivary glands from TGF-beta1/MHC class II double knockout mice were used to investigate the expression of adhesion molecules and MHC class II. In spite of the existence of basal intercellular adhesion molecule-1 expression on vessels, there was neither MHC class II expression, enhanced vascular cell adhesion molecule-1 expression, nor lymphocytic infiltration in the salivary glands. These results suggest that MHC class II plays a significant role in the pathogenesis of TGF-beta1 mutant mice. Although the mechanism that initiates multiple inflammatory diseases in these mice remains unclear, the context reported here would provide insight into the immunopathology of Sjögren's syndrome."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Dang H."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Ogawa N."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Kong L."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Nakabayashi T."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Koike T."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Geiser A.G."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Fernandes G."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Letterio J.J."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/author | "Talal N."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/pages | "5527-5535"xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/title | "Up-regulation of cytokine mRNA, adhesion molecule proteins, and MHC class II proteins in salivary glands of TGF-beta1 knockout mice: MHC class II is a factor in the pathogenesis of TGF-beta1 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://purl.uniprot.org/core/volume | "158"xsd:string |
| http://purl.uniprot.org/citations/9164977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9164977 |
| http://purl.uniprot.org/citations/9164977 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9164977 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-9164977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9164977 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-9164977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9164977 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-9164977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9164977 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-9164977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9164977 |
| http://purl.uniprot.org/uniprot/#_P04202-mappedCitation-9164977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9164977 |
| http://purl.uniprot.org/uniprot/#_P06342-mappedCitation-9164977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9164977 |