| http://purl.uniprot.org/citations/9169853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9169853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9169853 | http://www.w3.org/2000/01/rdf-schema#comment | "Pax-3 is a paired-type homeobox gene that is specifically expressed in the dorsal and posterior neural tube. We have investigated inductive interactions that initiate Pax-3 transcript expression in the early neural plate. We present several lines of evidence that support a model where Pax-3 expression is initiated by signals that posteriorize the neuraxis, and then secondarily restricted dorsally in response to dorsal-ventral patterning signals. First, in chick and Xenopus gastrulae the onset of Pax-3 expression occurs in regions fated to become posterior CNS. Second, Hensen's node and posterior non-axial mesoderm which underlies the neural plate induce Pax-3 expression when combined with presumptive anterior neural plate explants. In contrast, presumptive anterior neural plate explants are not competent to express Pax-3 in response to dorsalizing signals from epidermal-ectoderm. Third, in a heterospecies explant recombinant assay with Xenopus animal caps (ectoderm) as a responding tissue, late, but not early, Hensen's node induces Pax-3 expression. Chick posterior non-axial mesoderm also induces Pax-3, provided that the animal caps are neuralized by treatment with noggin. Finally we show that the putative posteriorizing factors, retinoic acid and bFGF, induce Pax-3 in neuralized animal caps. However, blocking experiments with a dominant-inhibitory FGF receptor and a dominant-inhibitory retinoic acid receptor suggest that Pax-3 inductive activities arising from Hensen's node and posterior non-axial mesoderm do not strictly depend on FGF or retinoic acid."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.124.10.2075"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.124.10.2075"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Kintner C."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Kintner C."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Papalopulu N."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Papalopulu N."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Bang A.G."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Bang A.G."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Goulding M.D."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/author | "Goulding M.D."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/pages | "2075-2085"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/pages | "2075-2085"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/title | "Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/title | "Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm."xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/9169853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9169853 |
| http://purl.uniprot.org/citations/9169853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9169853 |