| http://purl.uniprot.org/citations/9171108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9171108 | http://www.w3.org/2000/01/rdf-schema#comment | "The class II trans-activator (CIITA) is the main transcriptional co-activator for the expression of MHC class II proteins. Its N-terminal 125 amino acids function as an independent transcriptional activation domain. Analyses of the primary amino acid sequence of the activation domain predict the presence of three alpha-helices, each with a high proportion of acidic residues. Using site-directed mutagenesis, we found that two of these predicted alpha-helices are required for full transcriptional activation by CIITA. Moreover, a CIITA protein in which both functional alpha-helices have been deleted displays a dominant negative phenotype. This activation domain of CIITA interacts with the 32 kDa subunit of the general transcription complex TFIID, TAFII32. Decreased transcriptional activation by N-terminal deletions of CIITA is correlated directly with their reduced binding to TAFII32. We conclude that interactions between TAFII32 and CIITA are responsible for activation of class II genes."xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/25.12.2522"xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/author | "Jiang B."xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/author | "Peterlin B.M."xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/author | "Fontes J.D."xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/pages | "2522-2528"xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/title | "The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32."xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/9171108 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9171108 |
| http://purl.uniprot.org/citations/9171108 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9171108 |
| http://purl.uniprot.org/uniprot/P33076#attribution-0647A2D1CEE441E12D048A55388E100E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9171108 |
| http://purl.uniprot.org/uniprot/Q16594#attribution-0647A2D1CEE441E12D048A55388E100E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9171108 |