| http://purl.uniprot.org/citations/9171347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9171347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9171347 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of mouse platelets by collagen is associated with tyrosine phosphorylation of multiple proteins including the Fc receptor gamma-chain, the tyrosine kinase Syk and phospholipase Cgamma2, suggesting that collagen signals in a manner similar to that of immune receptors. This hypothesis has been tested using platelets from mice lacking the Fc receptor gamma-chain or Syk. Tyrosine phosphorylation of Syk and phospholipase Cgamma2 by collagen stimulation is absent in mice lacking the Fc receptor gamma-chain. Tyrosine phosphorylation of phospholipase Cgamma2 by collagen stimulation is also absent in mice platelets which lack Syk, although phosphorylation of the Fc receptor gamma-chain is maintained. In contrast, tyrosine phosphorylation of platelet proteins by the G protein-coupled receptor agonist thrombin is maintained in mouse platelets deficient in Fc receptor gamma-chain or Syk. The absence of Fc receptor gamma-chain or Syk is accompanied by a loss of secretion and aggregation responses in collagen-but not thrombin-stimulated platelets. These observations provide the first direct evidence of an essential role for the immunoreceptor tyrosine-based activation motif (ITAM) in signalling by a non-immune receptor stimulus."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.9.2333"xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/16.9.2333"xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Turner M."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Turner M."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Tybulewicz V.L."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Tybulewicz V.L."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Watson S.P."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Watson S.P."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Gibbins J.M."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Gibbins J.M."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Poole A."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "Poole A."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "van Vugt M.J."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "van Vugt M.J."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "van de Winkel J.G."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/author | "van de Winkel J.G."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9171347 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |