| http://purl.uniprot.org/citations/9171373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9171373 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell cycle arrest in G1 at the onset of patterning in the Drosophila eye is mediated by roughex. In roughex mutants, cells accumulate Cyclin A protein in early G1 and progress into S phase precociously. When Roughex is overexpressed in S/G2 cells, Cyclin A is mislocalized to the nucleus and degraded, preventing mitosis. Whereas Roughex inhibits Cyclin A accumulation, Cyclin E down-regulates Roughex protein in vivo. Roughex binds to Cyclin E and is a substrate for a Cyclin E-Cdk complex in vitro. These data argue that Roughex inhibits Cyclin A accumulation in early G1 by targeting Cyclin A for destruction. In late G1, Roughex is destabilized in a Cyclin E-dependent process, releasing Cyclin A for its role in S/G2."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.11.10.1289"xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Zavitz K.H."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Zipursky S.L."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Brent R."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Finley R.L. Jr."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Lehner C.F."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Weigmann K."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Lane M.E."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/author | "Thomas B.J."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/pages | "1289-1298"xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/title | "roughex down-regulates G2 cyclins in G1."xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/9171373 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9171373 |
| http://purl.uniprot.org/citations/9171373 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9171373 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI54-mappedCitation-9171373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9171373 |
| http://purl.uniprot.org/uniprot/#_A4V0R4-mappedCitation-9171373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9171373 |
| http://purl.uniprot.org/uniprot/#_E1JIR3-mappedCitation-9171373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9171373 |
| http://purl.uniprot.org/uniprot/#_M9NFR3-mappedCitation-9171373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9171373 |
| http://purl.uniprot.org/uniprot/#_P09081-mappedCitation-9171373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9171373 |
| http://purl.uniprot.org/uniprot/#_P10090-mappedCitation-9171373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9171373 |