| http://purl.uniprot.org/citations/9174623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9174623 | http://www.w3.org/2000/01/rdf-schema#comment | "The mouse Sry-like transcription factor Sox-4 is expressed in thymus, bone marrow, and gonads of adult mice. Sox-4-deficient mice die at embryonic day E14 due to cardiac malformation. In transfer experiments to irradiated recipients, B cell development was shown to be severely impaired in Sox-4-deficient progenitor cells. However, no drastic effects on T lymphocyte development were noted, despite the high level expression of the Sox-4 gene in the thymus of normal mice. Here, we report a detailed analysis of T cell development from Sox-4-deficient progenitors. Explanted fetal thymic organ cultures (FTOC) of Sox-4-deficient thymi yielded 10-50-fold fewer CD4 CD8 double-positive and single-positive cells than FTOC of littermates. This effect was T cell-autonomous, since similar observations were made when FTOC were performed by culturing of Sox-4-deficient progenitors in wild-type thymus lobes. When Sox-4-deficient fetal liver cells were injected together with normal cells intrathymically, they did not compete efficiently for reconstitution. It is concluded that Sox-4 facilitates thymocyte development."xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.1830270534"xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/author | "Clevers H.C."xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/author | "Cumano A."xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/author | "Schilham M.W."xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/author | "Moerer P."xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/pages | "1292-1295"xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/title | "Sox-4 facilitates thymocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/9174623 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q06831-mappedCitation-9174623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9174623 |
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