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http://purl.uniprot.org/citations/9175835http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9175835http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9175835http://www.w3.org/2000/01/rdf-schema#comment"Tip of herpesvirus saimiri associates with Lck and down-regulates Lck-mediated activation. We identified a novel cellular Tip-associated protein (Tap) by a yeast two-hybrid screen. Tap associated with Tip following transient expression in COS-1 cells and stable expression in human Jurkat-T cells. Expression of Tip and Tap in Jurkat-T cells induced dramatic cell aggregation. Aggregation was likely caused by the up-regulated surface expression of adhesion molecules including integrin alpha, L-selectin, ICAM-3, and H-CAM. Furthermore, NF-kappaB transcriptional factor of aggregated cells had approximately 40-fold higher activity than that of parental cells. Thus, Tap is likely to be an important cellular mediator of Tip function in T cell transformation by herpesvirus saimiri."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80345-3"xsd:string
http://purl.uniprot.org/citations/9175835http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80345-3"xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Lee H."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Lee H."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Jung J.U."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Jung J.U."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"DeMaria M."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"DeMaria M."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Rosenzweig M."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Rosenzweig M."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Seol W."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Seol W."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Yoon D.-W."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/author"Yoon D.-W."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/pages"571-582"xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/pages"571-582"xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/title"Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation."xsd:string
http://purl.uniprot.org/citations/9175835http://purl.uniprot.org/core/title"Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation."xsd:string