| http://purl.uniprot.org/citations/9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9178909 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently c-Cbl has been reported to be phosphorylated upon CSF-1 stimulation. The product of the c-cbl proto-oncogene (c-Cbl) is a 120 kDa protein harboring several docking sites for Src homology 2 (SH2) domain containing proteins and proline-rich regions that have been shown to allow its constitutive association with the SH3 domains of Grb2. We demonstrate here that CSF-1 exposure of stable transfectant CHO cells expressing the CSF-1 receptor induced the sustained tyrosine phosphorylation of c-Cbl and its subsequent association with Crk-II and the p85 kDa subunit of the PI 3-kinase, while it constitutively associates with Grb2. We demonstrate by in vitro experiments that these associations require the SH2 domain of Crk-II and both the C- and N-terminal SH2 domains of the p85 subunit of the PI 3-kinase. cCbl is the major PI 3-kinase-containing protein in c-Fms expressing CHO cells upon CSF-1 stimulation. Thus c-Cbl behaves as a core protein, allowing the formation of a quaternary complex including, Crk-II, PI 3-kinase and Grb2. We provide evidence that this multiprotein complex can interact with the tyrosine phosphorylated CSF-1 receptor through the unoccupied SH2 domain of Grb2."xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1201074"xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/author | "Fischer S."xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/author | "Husson H."xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/author | "Rossi B."xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/author | "Mograbi B."xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/author | "Schmid-Antomarchi H."xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/pages | "2331-2338"xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/title | "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2."xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/9178909 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9178909 |
| http://purl.uniprot.org/citations/9178909 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9178909 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_P06241-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_P27986-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_O75791-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_P42338-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_O15357-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_P16885-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_P07947-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_P07948-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |
| http://purl.uniprot.org/uniprot/#_P08631-mappedCitation-9178909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9178909 |