| http://purl.uniprot.org/citations/9182768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9182768 | http://www.w3.org/2000/01/rdf-schema#comment | "During the nucleolar maturation of eukaryotic ribosomal RNAs, many selected uridines are converted into pseudouridine by a thus far undefined mechanism. The nucleolus contains a large number of small RNAs (snoRNAs) that share two conserved sequence elements, box H and ACA. In this study, we demonstrate that site-specific pseudouridylation of rRNAs relies on short ribosomal signal sequences that are complementary to sequences in box H/ACA snoRNAs. Genetic depletion and reconstitution studies on yeast snR5 and snR36 snoRNAs demonstrate that box H/ACA snoRNAs function as guide RNAs in rRNA pseudouridylation. These results define a novel function for snoRNAs and further reinforce the idea that base pairing is the most common way to obtain specific substrate-"enzyme" interactions during rRNA maturation."xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80263-9"xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/author | "Kiss T."xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/author | "Ganot P."xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/author | "Bortolin M.L."xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/pages | "799-809"xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/title | "Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs."xsd:string |
| http://purl.uniprot.org/citations/9182768 | http://purl.uniprot.org/core/volume | "89"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P32495-mappedCitation-9182768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9182768 |
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| http://purl.uniprot.org/uniprot/P33322 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9182768 |
| http://purl.uniprot.org/uniprot/P32495 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9182768 |
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