| http://purl.uniprot.org/citations/9186903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9186903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9186903 | http://www.w3.org/2000/01/rdf-schema#comment | "In humans, both the expression of apobec-1 and the C to U deamination of apoB mRNA are confined to the small intestine. In order to understand the tissue-restricted pattern of apobec-1 expression, we have isolated the chromosomal gene spanning the human apobec-1 locus. The human apobec-1 gene spans 18 kb and contains five exons, all of which are translated. Transcription initiation, determined by RNase protection and primer extension analyses, is localized to a single start site 34 nt upstream of the open-reading frame in exon 1. A common, but functionally silent, gene polymorphism was detected than changes Ilc80 to MCl. RNase protection and reverse-transcription PCR analysis demonstrated the presence of an exon 2-skipped form of apobec-1 mRNA that arises through use of an alternative splice acceptor. This alternative splicing causes a frame-shift that produces a novel, 36 amino acid peptide. The exon 2-skipped form accounts for approximately 50% of apobec-1 mRNA in the adult small intestine and up to 90% of apobec-1 mRNA in the developing gut. An antipeptide antibody identified the truncated protein in villus cells of the adult small intestine. These data suggest that exon 2-skipping may represent an important control mechanism regulating apobec-1 gene expression in humans."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Funahashi T."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Funahashi T."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Min J."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Min J."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Davidson N.O."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Davidson N.O."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Hirano K."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Hirano K."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Baunoch D.A."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/author | "Baunoch D.A."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/name | "J. Lipid Res."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/name | "J. Lipid Res."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/pages | "847-859"xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/pages | "847-859"xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/title | "Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/title | "Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide."xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/9186903 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9186903 |
| http://purl.uniprot.org/citations/9186903 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9186903 |