| http://purl.uniprot.org/citations/9187657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9187657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9187657 | http://www.w3.org/2000/01/rdf-schema#comment | "The Erm family of methyltransferases is responsible for the development of resistance to the macrolide-lincosamide-streptogramin type B (MLS) antibiotics. These enzymes methylate an adenine of 23S ribosomal RNA that prevents the MLS antibiotics from binding to the ribosome and exhibiting their antibacterial activity. Here we describe the three-dimensional structure of an Erm family member, ErmAM, as determined by NMR spectroscopy. The catalytic domain of ErmAM is structurally similar to that found in other methyltransferases and consists of a seven-stranded beta-sheet flanked by alpha-helices and a small two-stranded beta-sheet. In contrast to the catalytic domain, the substrate binding domain is different from other methyltransferases and adopts a novel fold that consists of four alpha-helices."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0697-483"xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsb0697-483"xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Petros A.M."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Petros A.M."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Zhong P."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Zhong P."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Walter K."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Walter K."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Fesik S.W."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Fesik S.W."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Schnuchel A."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Schnuchel A."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Holzman T.F."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Holzman T.F."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Severin J.M."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/author | "Severin J.M."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/9187657 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |