| http://purl.uniprot.org/citations/9188502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9188502 | http://www.w3.org/2000/01/rdf-schema#comment | "Resistance to radiation leukemia virus-induced leukemia is correlated with an increase in H-2D expression on the thymocyte surface. Recently, it has been shown that elevated H-2Dd expression on the infected thymocyte is a result of elevated mRNA transcription and that the transcriptional increase is correlated with elevated levels of a DNA binding activity, H-2 binding factor 1 (H-2 BF1), which recognizes the 5'-flanking sequences (5'-TGACGCG-3') of the H-2Dd gene. This target for transcription factor binding has been found to be identical in the 5'-regulatory region of 12 rodent class I genes, nine of which have been shown to be functional genes. Furthermore, this cis-element is found 5' of 20 primate class I genes (15 human genes), seven of which are known to be functional. Here, we demonstrate that activation transcription factor 1 (ATF-1) is one component of H-2 BF1. In addition, the levels of ATF-1 mRNA in uninfected and radiation leukemia virus-infected thymocytes parallel those of H-2Dd mRNA, and therefore, it is suggested that ATF-1 up-regulates the transcription of the H-2Dd gene after radiation leukemia virus infection of thymocytes. Transfection experiments also demonstrate that ATF-1 activates a reporter plasmid that contains the H-2 BF1 motif, but not a reporter lacking this motif. This is the first demonstration of the interaction of ATF-1 with 5'-regulatory sequences of major histocompatibility complex class I genes."xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.25.15993"xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/author | "Brown G.D."xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/author | "Ishiguro N."xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/author | "Meruelo D."xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/pages | "15993-16001"xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/title | "Activation transcription factor 1 involvement in the regulation of murine H-2Dd expression."xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9188502 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9188502 |
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| http://purl.uniprot.org/uniprot/#_F6U840-mappedCitation-9188502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9188502 |
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| http://purl.uniprot.org/uniprot/#_E9PYW2-mappedCitation-9188502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9188502 |
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| http://purl.uniprot.org/uniprot/#_Q922R4-mappedCitation-9188502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9188502 |
| http://purl.uniprot.org/uniprot/#_P81269-mappedCitation-9188502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9188502 |
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| http://purl.uniprot.org/uniprot/F6U840 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9188502 |