| http://purl.uniprot.org/citations/9199344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9199344 | http://www.w3.org/2000/01/rdf-schema#comment | "Cross-linking of the B-cell antigen receptor (BCR) induces tyrosine phosphorylation of Shc, which is believed to lead to the activation of Ras. Previous work has shown that tyrosine-phosphorylated Shc forms complexes with another adapter protein, Grb2, and the Ras guanine nucleotide exchange factor SOS. Here, we demonstrate that phosphorylation of Shc by the hematopoietic cell-specific tyrosine kinase Syk induces binding of Grb2 to Shc, suggesting that Syk phosphorylates Shc in stimulated B cells. Surprisingly, Syk-phosphorylated Shc possesses two Grb2 binding sites rather than the one site that has been previously reported. Both of these sites are required for efficient formation of Shc-Grb2-SOS complexes in vitro and in vivo. We suggest that two Grb2 proteins anchored by a single Shc protein bind simultaneously to one SOS molecule, resulting in a complex that is more stable than a complex containing only a single Grb2 protein bound to one SOS molecule. This model is consistent with our observation that BCR stimulation greatly increases the amount of SOS associated with Grb2."xsd:string |
| http://purl.uniprot.org/citations/9199344 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.17.7.4087"xsd:string |
| http://purl.uniprot.org/citations/9199344 | http://purl.uniprot.org/core/author | "Harmer S.L."xsd:string |
| http://purl.uniprot.org/citations/9199344 | http://purl.uniprot.org/core/author | "DeFranco A.L."xsd:string |
| http://purl.uniprot.org/citations/9199344 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9199344 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9199344 | http://purl.uniprot.org/core/pages | "4087-4095"xsd:string |
| http://purl.uniprot.org/citations/9199344 | http://purl.uniprot.org/core/title | "Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/9199344 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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