| http://purl.uniprot.org/citations/9208140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9208140 | http://www.w3.org/2000/01/rdf-schema#comment | "1. Effects of an orally active non-peptide (BK) B2 receptor antagonist, FR173657 ((E)-3-(6-acetamido-3-pyridyl)-N-[N-[2,4-dichloro-3-[(2-methyl-8-quinoli nyl) oxymethyl]phenyl]-N-methylaminocarbonylmethyl] acrylamide) on the plasma exudation in rat carrageenin-induced pleurisy were investigated. 2. Plasma exudation induced by intrapleural injection of bradykinin (BK, 3 nmol per rat) into male SD strain rats (SPF, 8 weeks old) were significantly inhibited by oral administration of novel B2 receptor antagonist FR173657 (3-30 mg kg-1, 1 h before BK injection) in a dose-dependent manner, whereas that induced by histamine was not. 3. The inhibitory effect of 30 mg kg-1 FR173657 persisted for more than 4 h. 4. Intrapleural injection of lambda-carrageenin (2% (w/v), 0.1 ml per rat) caused marked plasma exudation and accumulation of exudates from 1 h after carrageenin injection. The maximum plasma exudation response was observed 5 h after carrageenin. The oral administration of FR173657 to rats (30 mg kg-1, 1 h before carrageenin) significantly (by 50-77%) blunted the plasma exudation 1, 3, 5, and 7 h after carrageenin, causing a significant parallel reduction (by 42-57%) in the volume of exudates. 5. The anti-inflammatory effect of FR173657 on rat carrageenin-induced pleurisy was almost equipotent with that of the peptide B2 antagonist Hoe140 (1 mg kg-1, i.v.), a plasma kallikrein inhibitor, soy bean trypsin inhibitor (0.3 mg per rat, intrapleural injection) and bromelain (10 mg kg-1, i.v.). 6. In pleurisy induced by intrapleural injection of a histamine releaser, compound 48/80, the plasma exudation was observed only within 20 min after the injection. This plasma exudation was not affected by FR173657, although it was completely inhibited by a mixture of pyrilamine (5 mg kg-1, i.v.) and methysergide (3 mg kg-1, i.v.). 7. These results indicate that FR173657 is an orally active, promising anti-inflammatory agent for kinin-dependent inflammation."xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.bjp.0701194"xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/author | "Kawashima N."xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/author | "Hiroshi I."xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/author | "Majima M."xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/author | "Katori M."xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/name | "Br J Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/pages | "723-730"xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/title | "Effects of an orally active non-peptide bradykinin B2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy."xsd:string |
| http://purl.uniprot.org/citations/9208140 | http://purl.uniprot.org/core/volume | "121"xsd:string |
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