| http://purl.uniprot.org/citations/9208839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9208839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9208839 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of immature CD4+ CD8+ thymocytes into functionally mature CD4+ and CD8+ T cells is driven by selection events that require signals transduced through the T cell antigen receptor (TCR). Transduction of TCR signals in the thymus involves tyrosine phosphorylation of the protein tyrosine kinase ZAP-70 by p56(lck) and results in induction of ZAP-70 enzymatic activity. We have identified a novel, spontaneously arising point mutation within a highly conserved motif (DLAARN) in the kinase domain of murine ZAP-70 that uncouples tyrosine phosphorylation of ZAP-70 from induction of ZAP-70 kinase activity. Mice homozygous for this mutation are devoid of mature T cells because thymocyte development is arrested at the CD4+ CD8+ stage of differentiation. The developmental arrest is due to the inability of CD4+ CD8+ thymocytes to propagate TCR signals in the absence of ZAP-70 kinase activity despite tyrosine phosphorylation of TCR-associated ZAP-70 molecules."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(00)80442-2"xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(00)80442-2"xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Abe R."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Abe R."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Lee H.-M."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Lee H.-M."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Singer A."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Singer A."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Negishi I."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Negishi I."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Wiest D.L."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Wiest D.L."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Singer D.S."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Singer D.S."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Howcroft T.K."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Howcroft T.K."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Ashe J.M."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Ashe J.M."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Kemper D.M."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/author | "Kemper D.M."xsd:string |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9208839 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |