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http://purl.uniprot.org/citations/9212230http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9212230http://www.w3.org/2000/01/rdf-schema#comment"We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. We have previously shown that the expression of exogenous Egr-1 in human breast and other tumor cells markedly reduces transformed growth and tumorigenicity. We therefore hypothesized that the loss of Egr-1 expression plays a role in transformation. All human and mouse breast cancer cell lines and tumors examined had reduced Egr-1 expression compared with their normal counterparts. Reduced Egr-1 expression was also observed in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors, and this level increased to normal levels in tumors that regressed after tamoxifen treatment. We concluded, therefore, that loss of Egr-1 expression may play a role in the deregulation of normal growth in the tumorigenic process and that Egr-1 acts as a tumor suppressor gene."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.org/dc/terms/identifier"doi:10.1002/(sici)1097-0215(19970703)72:1<102::aid-ijc15>3.0.co;2-l"xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/author"Fan Y."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/author"Huang R.P."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/author"Gottardis M.M."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/author"Adamson E.D."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/author"Mercola D."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/author"Niemeyer C."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/author"de Belle I."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/name"Int J Cancer"xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/pages"102-109"xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/title"Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation."xsd:string
http://purl.uniprot.org/citations/9212230http://purl.uniprot.org/core/volume"72"xsd:string
http://purl.uniprot.org/citations/9212230http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9212230
http://purl.uniprot.org/citations/9212230http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9212230
http://purl.uniprot.org/uniprot/#_A0A0H2UHR3-mappedCitation-9212230http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9212230
http://purl.uniprot.org/uniprot/#_P08154-mappedCitation-9212230http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9212230
http://purl.uniprot.org/uniprot/A0A0H2UHR3http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/9212230
http://purl.uniprot.org/uniprot/P08154http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/9212230