| http://purl.uniprot.org/citations/9218477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9218477 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9218477 | http://www.w3.org/2000/01/rdf-schema#comment | "Agonist-sensitive phosphoinositide pools are maintained by recently-identified wortmannin (WT)-sensitive phosphatidylinositol (PI) 4-kinase(s) (Nakanishi, S., Catt, K. J., and Balla, T. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 5317-5321). Two loosely membrane-associated WT-sensitive type III PI 4-kinases were isolated from bovine adrenal cortex as [3H]WT-labeled 110- and 210-kDa proteins. Based on peptide sequences from the smaller enzyme, a 3. 9-kilobase pair (kb) cDNA with an open reading frame encoding a 90-kDa protein was isolated from a bovine brain cDNA library. Expression of this cDNA in COS-7 cells yielded a 110-kDa protein with WT-sensitive PI 4-kinase activity. Northern blot analysis of a human mRNA panel showed a single approximately 3.8-kb transcript. Peptide sequences obtained from the 210-kDa enzyme corresponded to those of a recently described rat 230-kDa PI 4-kinase. A 6.5-kb cDNA containing an open reading frame of 6129 nucleotides that encoded a 230-kDa protein, was isolated from brain cDNA. Northern blot analysis of human mRNA revealed a major 7.5-kb transcript. The molecular cloning of these novel WT-sensitive type III PI 4-kinases will allow detailed analysis of their signaling and other regulatory functions in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.29.18358"xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.29.18358"xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Jaffe H."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Jaffe H."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Catt K.J."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Catt K.J."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Balla T."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Balla T."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Downing G.J."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Downing G.J."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Zolyomi A."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/author | "Zolyomi A."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/pages | "18358-18366"xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/pages | "18358-18366"xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/title | "Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases."xsd:string |
| http://purl.uniprot.org/citations/9218477 | http://purl.uniprot.org/core/title | "Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases."xsd:string |