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http://purl.uniprot.org/citations/9219694http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9219694http://www.w3.org/2000/01/rdf-schema#comment"Proteins of the Bcl-2 family are intracellular membrane-associated proteins that regulate programmed cell death (apoptosis) either positively or negatively by as yet unknown mechanisms. Bax, a pro-apoptotic member of the Bcl-2 family, was shown to form channels in lipid membranes. Bax triggered the release of liposome-encapsulated carboxyfluorescein at both neutral and acidic pH. At physiological pH, release could be blocked by Bcl-2. Bcl-2, in contrast, triggered carboxyfluorescein release at acidic pH only. In planar lipid bilayers, Bax formed pH- and voltage-dependent ion-conducting channels. Thus, the pro-apoptotic effects of Bax may be elicited through an intrinsic pore-forming activity that can be antagonized by Bcl-2."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.org/dc/terms/identifier"doi:10.1126/science.277.5324.370"xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Lewis S."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Sadoul R."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Bernard A."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Martinou J.C."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Maundrell K."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Martinou I."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Gambale F."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Antonsson B."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Montessuit S."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Bernasconi L."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Conti F."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Ciavatta A."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Mazzei G."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/author"Mermod J.J."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/date"1997"xsd:gYear
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/pages"370-372"xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/title"Inhibition of Bax channel-forming activity by Bcl-2."xsd:string
http://purl.uniprot.org/citations/9219694http://purl.uniprot.org/core/volume"277"xsd:string
http://purl.uniprot.org/citations/9219694http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9219694
http://purl.uniprot.org/citations/9219694http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9219694
http://purl.uniprot.org/uniprot/P10415#attribution-D8CB4774B7A8AC2910E4C45F852E600Dhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/9219694