| http://purl.uniprot.org/citations/9223106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9223106 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9223106 | http://www.w3.org/2000/01/rdf-schema#comment | "One approach to understanding the function of presenilin 1 (PS1), is to discover those proteins with which it interacts. Evidence for a function in developmental patterning came from C. elegans, in which a PS homologue was identified by screening for suppressors of a mutation in Notch/lin-12, a gene which specifies cell fate. However, this genetic experiment cannot determine which proteins directly interact with PS1. Therefore, we utilized the two hybrid system and confirmatory co-immunoprecipitations to identify a novel catenin, termed delta-catenin, which interacts with PS1 and is principally expressed in brain. The catenins are a gene family related to the Armadillo gene in Drosophila, some of which appear to have dual roles-they are components of cell-cell adherens junctions, and may serve as intermediates in the Wingless (Wg) signaling pathway, which, like Notch/lin-12, is also responsible for a variety of inductive signaling events. In the non-neuronal 293 cell line, PS1 interacted with beta-catenin, the family member with the greatest homology to Armadillo. Wg and Notch interactions are mediated by the Dishevelled gene, which may form a signaling complex with PS1 and Wg pathway intermediates to regulate the function of the Notch/lin-12 gene."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.org/dc/terms/identifier | "doi:10.1097/00001756-199705260-00054"xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.org/dc/terms/identifier | "doi:10.1097/00001756-199705260-00054"xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Ho C."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Ho C."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Kosik K.S."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Kosik K.S."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Medina M."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Medina M."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Lovett M."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Lovett M."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Liyanage U."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Liyanage U."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Simmons A.D."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/author | "Simmons A.D."xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/name | "NeuroReport"xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/name | "NeuroReport"xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/pages | "2085-2090"xsd:string |
| http://purl.uniprot.org/citations/9223106 | http://purl.uniprot.org/core/pages | "2085-2090"xsd:string |