| http://purl.uniprot.org/citations/9223278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9223278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9223278 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF-kappaB/Rel proteins are sequestered in the cytoplasm in association with IkappaBalpha. In response to external signals, IkappaBalpha is phosphorylated, multi-ubiquitinated, and degraded by proteasomes, thereby releasing NF-kappaB/Rel proteins to migrate to the nucleus. We have cloned a mouse ubiquitin-conjugating enzyme (mE2), which associates with IkappaBalpha. mE2 is homologous to the yeast Ubc9/Hus5 ubiquitin-conjugating enzyme. A transdominant-negative mutant of mE2 had no effect on phosphorylation of IkappaBalpha, but delayed its degradation. Correspondingly, tumor necrosis factor-alpha-inducible NF-kappaB activity was diminished. We propose that mE2 is directly involved in the ubiquitin conjugation of IkappaBalpha, a pivotal step in its degradation pathway."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.15.7862"xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.94.15.7862"xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Tashiro K."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Tashiro K."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Verma I.M."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Verma I.M."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Kanegae Y."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Kanegae Y."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Pando M.P."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Pando M.P."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Wamsley P.M."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/author | "Wamsley P.M."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/pages | "7862-7867"xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/pages | "7862-7867"xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/title | "Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha."xsd:string |
| http://purl.uniprot.org/citations/9223278 | http://purl.uniprot.org/core/title | "Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha."xsd:string |