| http://purl.uniprot.org/citations/9242702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9242702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9242702 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytotoxic lymphocytes contain granules that have the ability to induce apoptosis in susceptible target cells. The granule contents include perforin, a pore-forming molecule, and several granzymes, including A and B, which are the most abundant serine proteases in these granules. Granzyme B-deficient cytotoxic T lymphocytes (CTL) have a severe defect in their ability to rapidly induce apoptosis in their targets, but have an intact late cytotoxicity pathway that is in part perforin-dependent. In this report, we have created mice that are deficient for granzyme A and characterized their phenotype. These mice have normal growth and development and normal lymphocyte development, activation, and proliferation. Granzyme A-deficient CTL have a small but reproducible defect in their ability to induce 51Cr and 125I-UdR release from susceptible allogeneic target cells. Since other granzyme A-like tryptases could potentially account for the residual cytotoxicity in granzyme A-deficient CTL, we cloned the murine granzyme K gene, which is linked to granzyme A in humans, and proved that it is also tightly linked with murine granzyme A. The murine granzyme K gene (which encodes a tryptase similar to granzyme A) is expressed at much lower levels than granzyme A in CTL and LAK cells, but its expression is unaltered in granzyme A-/- mice. The minimal cytotoxic defect in granzyme A-/-CTL could be due to the existence of an intact, functional early killing pathway (granzyme B dependent), or to the persistent expression of additional granzyme tryptases like granzyme K."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.32.20236"xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.272.32.20236"xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Ley T.J."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Ley T.J."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Goda P."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Goda P."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Shresta S."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Shresta S."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Wesselschmidt R."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/author | "Wesselschmidt R."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/pages | "20236-20244"xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/pages | "20236-20244"xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/title | "Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/title | "Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://purl.uniprot.org/core/volume | "272"xsd:string |
| http://purl.uniprot.org/citations/9242702 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9242702 |
| http://purl.uniprot.org/citations/9242702 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9242702 |