| http://purl.uniprot.org/citations/9247316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9247316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9247316 | http://www.w3.org/2000/01/rdf-schema#comment | "Flt4 is a receptor protein tyrosine kinase that is expressed in the adult lymphatic endothelium and high endothelial venules. We have used a BIAcore assay to identify rodent and human cell conditioned media containing the ligand of Flt4 (Flt4-L). Receptor-based affinity chromatography was used to purify this growth factor, followed by amino acid sequencing and molecular cloning of the murine cDNA, the orthologue of human vascular endothelial growth factor-C and vascular endothelial growth factor related protein. The murine flt4-L gene was localized to chromosome 8 and demonstrated to be widely expressed. Flt4-L was found to have a hydrophobic signal sequence and a pro-peptide-like sequence that is removed to generate the mature N-terminus. In addition, the C-terminal region of Flt4-L has four repeats of a cysteine-rich motif that is presumably also proteolytically processed to generate the 21000 Mr polypeptide subunit of the Flt4-L homodimer. Recombinant Flt4-L activated Flt4 as judged by induction of tyrosyl phosphorylation, and induced mitogenesis in vitro of lymphatic endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1201191"xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1201191"xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Long A."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Long A."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Morris J.C."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Morris J.C."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Towler P."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Towler P."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Greco R."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Greco R."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Turner K.J."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Turner K.J."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Beier D.R."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Beier D.R."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Nickbarg E."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Nickbarg E."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Kovacic S."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Kovacic S."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Zollner R."xsd:string |
| http://purl.uniprot.org/citations/9247316 | http://purl.uniprot.org/core/author | "Zollner R."xsd:string |