| http://purl.uniprot.org/citations/9254656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9254656 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytosolic SHP-1 and transmembrane CD45 protein tyrosine phosphatases (PTP) play critical roles in regulating signal transduction via the B cell antigen receptor (BCR). These PTPs differ, however, in their effects on BCR function. For example, BCR-mediated mitogenesis is essentially ablated in mice lacking CD45 (CD45(-)), but is enhanced in SHP-1-deficient motheaten (me) and viable motheaten (mev) mice. To determine whether these PTPs act independently or coordinately in modulating the physiologic outcome of BCR engagement, we assessed B cell development and signaling in CD45-deficient mev (CD45-/SHP-1-) mice. Here we report that the CD45-/SHP-1-) cells undergo appropriate induction of protein kinase activity, mitogen-activated protein kinase activation, and proliferative responses after BCR aggregation. However, BCR-elicited increases in the tyrosine phosphorylation of several SHP-1-associated phosphoproteins, including CD19, were substantially enhanced in CD45-/SHP-1-, compared to wild-type and CD45-cells. In addition, we observed that the patterns of cell surface expression of mu, delta, and CD5, which distinguish the PTP-deficient from normal mice, are largely restored to normal levels in the double mutant animals. These findings indicate a critical role for the balance of SHP-1 and CD45 activities in determining the outcome of BCR stimulation and suggest that these PTPs act in a coordinate fashion to couple antigen receptor engagement to B cell activation and maturation."xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.186.4.581"xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/author | "Siminovitch K.A."xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/author | "Paige C.J."xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/author | "Pani G."xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/pages | "581-588"xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/title | "The motheaten mutation rescues B cell signaling and development in CD45-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/9254656 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9254656 |
| http://purl.uniprot.org/citations/9254656 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9254656 |
| http://purl.uniprot.org/uniprot/P25918#attribution-E7EDB23A826F1CC80A2EEC407E21CBE0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/P01872#attribution-E7EDB23A826F1CC80A2EEC407E21CBE0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/P63085#attribution-E7EDB23A826F1CC80A2EEC407E21CBE0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/P29351#attribution-6262FE6E8896C3E95AB7EBF9574381C1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/P06800#attribution-6262FE6E8896C3E95AB7EBF9574381C1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/A0A0A6YW14#attribution-E7EDB23A826F1CC80A2EEC407E21CBE0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/A0A0A6YXD7#attribution-E7EDB23A826F1CC80A2EEC407E21CBE0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW14-mappedCitation-9254656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-9254656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXD7-mappedCitation-9254656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-9254656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9254656 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-9254656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9254656 |