| http://purl.uniprot.org/citations/9271117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9271117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9271117 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of AP-2 transcription factors has been detected previously in embryonic renal tissues. We show here that AP-2beta -/-mice complete embryonic development and die at postnatal days 1 and 2 because of polycystic kidney disease. Analyses of kidney development revealed that induction of epithelial conversion, mesenchyme condensation, and further glomerular and tubular differentiation occur normally in AP-2beta-deficient mice. At the end of embryonic development expression of bcl-X(L), bcl-w, and bcl-2 is down-regulated in parallel to massive apoptotic death of collecting duct and distal tubular epithelia. Addressing the molecular mechanism we show that transfection of AP-2 into cell lines in vitro strongly suppresses c-myc-induced apoptosis pointing to a function of AP-2 in programming cell survival during embryogenesis. The position of the human AP-2beta gene was identified at chromosome 6p12-p21.1, within a region that has been mapped for autosomal recessive polycystic kidney disease (ARPKD). Sequence analyses of ARPKD patients and linkage analyses using intragenic polymorphic markers indicate that the AP-2beta gene is located in close proximity to but distinct from the ARPKD gene."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.11.15.1938"xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.11.15.1938"xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/author | "Moser M."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/author | "Buettner R."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/author | "Buettner R."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/pages | "1938-1948"xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/pages | "1938-1948"xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/title | "Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/title | "Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta."xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/9271117 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9271117 |
| http://purl.uniprot.org/citations/9271117 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9271117 |
| http://purl.uniprot.org/citations/9271117 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9271117 |
| http://purl.uniprot.org/citations/9271117 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9271117 |
| http://purl.uniprot.org/uniprot/Q92481 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9271117 |
| http://purl.uniprot.org/embl-cds/CAA71047.1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9271117 |