| http://purl.uniprot.org/citations/9271586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9271586 | http://www.w3.org/2000/01/rdf-schema#comment | "Ly-6A is a murine antigen which is implicated in lymphocyte activation and may be involved in activation of hematopoietic stem cells. Antibody cross-linking studies and antisense experiments have suggested that Ly-6A is a lymphocyte coactivation molecule. To better understand the function of Ly-6A, we used gene targeting to produce Ly-6A null mice which are healthy and have normal numbers and percentages of hematopoietic lineages. However, T lymphocytes from Ly-6A-deficient animals proliferate at a significantly higher rate in response to antigens and mitogens than wild-type littermates. In addition, Ly-6A mutant splenocytes generate more cytotoxic T lymphocytes compared to wild-type splenocytes when cocultured with alloantigen. This enhanced proliferation is not due to alterations in kinetics of response, sensitivity to stimulant concentration, or cytokine production by the T cell population, and is manifest in both in vivo and in vitro T cell responses. Moreover, T cells from Ly-6A-deficient animals exhibit a prolonged proliferative response to antigen stimulation, thereby suggesting that Ly-6A acts to downmodulate lymphocyte responses."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.186.5.705"xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Stanford W.L."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Alexander R."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Haque S."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Koller B.H."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Snodgrass H.R."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Latour A.M."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/author | "Flood P.M."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/date | "1997"xsd:gYear |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/pages | "705-717"xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/title | "Altered proliferative response by T lymphocytes of Ly-6A (Sca-1) null mice."xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/9271586 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9271586 |
| http://purl.uniprot.org/citations/9271586 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9271586 |
| http://purl.uniprot.org/uniprot/#_A0A087WNT7-mappedCitation-9271586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9271586 |
| http://purl.uniprot.org/uniprot/#_P05533-mappedCitation-9271586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9271586 |
| http://purl.uniprot.org/uniprot/A0A087WNT7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9271586 |
| http://purl.uniprot.org/uniprot/P05533 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/9271586 |